CBNVA (Cannabinovarinic Acid)

A method for demethylating a methylated phytocannabinoid compound of Formula I to form a phytocannabinoid compound of Formula II: OH O OH O R3 0 Me 0 R3 OH R2 R1 R2 R1 Formula I Formula II wherein: 5 R1 is selected from the group consisting of: substituted or unsubstituted C1-C5 alkyl; R2 is selected from the group consisting of: OH or 0, and R3 is selected from the group consisting of: a substituted or unsubstituted cyclohexene, a substituted or unsubstituted C2-C0 alkene, or a substituted or unsubstituted C2-C dialkene; or R2 is 0, 10 and R2 and R3 together form a ring structure in which R2 is an internal ring atom; wherein the method includes: heating a reaction mixture comprising the methylated phytocannabinoid compounds and a polar aprotic solvent in the presence of a dissolved inorganic alkaline salt for a time sufficient to demethylate at least a portion of the methylated 15 phytocannabinoid compounds and form the phytocannabinoid compound.

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